Research areas

The faculty of the Department of Sport Medicine is specialized in the areas of sport-related biomechanics and physiology. The research in the Department includes the muscle performance (as indicated by EMGs and force outputs), force impacts of different parts of body and joints, motion analysis, heart rate variability, blood pressure control, food intake behavior and physiology, and body weights control, which encompasses a variety of sciences from biomechanics to systemic physiology, biochemistry and molecular biology.


Dr. Huei-Ju Wang: Carcinogenic gene expressions in malignant tumors of skeletal muscles

Prognosis for malignant skeletal muscle tumors would primarily depend on the TNM (Tumor development, Nymph affect, and migration) staging system and the responses of the patients to the therapy. Unfortunately, tumors of similar stage with similar therapy may not have similar outcomes. Recent studies suggest that other biological factors, for example, over production of certain gene products, such as c-Fos,c-Myc, P-glycoprotein and HER2, may be closely related to the prognosis of the malignant skeletal muscle tumors.

Correlation between physical fitness and indices of oxidative stress in adults

Our research revealed that both body fats (%) and VO2max were increased after exercise training, which would be accompanied by significant decreases in heart rates, but not with body weights or waist-hip circumflexes ratios.

Research Interests

  • Animal models of amnesia and drug therapy evaluation
  • Analysis of factors for skeletal muscle tumor prognosis
  • Gene expression in malignant skeletal muscle tumors
  • Effects of aerobic exercise on eotaxin in young women and its correlation to anthropometry
  • Effects of exercise at different time on insulin

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Dr. Bao-Lien Hung: Standing by the patients; knowledgeable others; socialconstructivism; doctor-patient relationship; medical education

How to nourish today’s medical students to become tomorrow's good doctors is a difficult task. It was found in literature that educating students treat patients as teachers not only strengthened medical skill learning but also develops students' attitude to serve patients as relatives. This study intended to investigate the effect of a course "Standing by the Patients" on medical students. Learning over a two-year period, 138 medical students taking the course were invited to respond open-ended questionnaires. The data collected were analyzed on the basis of social constructivism. The results are classified into four main parts, consisting of 32 subcategories. Which can be boiled down to a new understanding of doctor-patient relationship. After the hands-on experience of caring the invalid, could respect patients as their knowledgeable others and are more ready and willing to listen to them and to learn from them. In summary, the course "Standing by the Patients" is beneficial for medical student’s learning. The findings of this study hopefully may provide useful information for the advancement of medical education.

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Dr. Jwo-Sheng Chen: Effects of exercise on the cardiovascular function and the changes of cardiovascular system in response to exercise.

The research interest of this laboratory is primarily focused on the effects of exercise on the cardiovascular function and the changes of cardiovascular system in response to exercise. We investigate the blood pressure control mechanisms, heart rate variability, and cardiovascular autonomic nervous function and hormonal and humoral factors during acute and chronic exercise.
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Dr. Teng-Le Huang: Hyaluronan up-regulates IL-10 expression in fibroblast-like synoviocytes from patients with tibia plateaufracture.

Progression to osteoarthritis (OA) is a frequent sequela of severe articular fracture, particularly when weight-bearing joints are involved. Prevention from post-traumatic OA remains a challenge. Hyaluronan (HA) therapy is reported to represent a safe and effective treatment for patients with OA and rheumatoid arthritis. However, the capacity of HA to prevent the occurrence of osteoarthritic changes in fractured joints has not been demonstrated. The present study was undertaken to examine the effects of HA on expression of six OA-related proteins in fibroblast-like synoviocytes (FLS) from 10 patients with tibia plateau fracture. OA-related factors were quantified using a sandwich enzyme-linked immunosorbent assay. Regardless of induction of the FLS with interleukin (IL)-1β, HA was found to down-regulate expression of catabolic factors (IL-1β, matrix metalloproteinase-3, and tumor necrosis factor-α) and to up-regulate production of anti-catabolic factors (tissue inhibitors of metalloproteinase-1 and metalloproteinase-2). HA also enhanced expression of IL-10, an anti-inflammatory cytokine, in FLS. Our results indicated that HA can promote the expression of both antiinflammatory and structure-protective factors in FLS of patients with tibia plateau fracture.

Research Interests

  • Biomaterial, Biomedical engineering
  • Hyaluronic acid
  • Molecular biology in osteoarthritis, especially focus on Fibroblast-like synoviocyte
  • Prognostic factors analysis in orthopedic trauma surgery and oncologic surgery
  • Molecular cell biology in tumor metastasis

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Dr. Wei-Hsien Hong: Musculoskeletal injury in sports and functional activities.

My researches mainly focused on investigating the risk of musculoskeletal injury in sports and functional activities in athletes, non-athletes, and individuals with disability. Moreover, I also applied ergonomics interventions in the following sectors: industry-based manual handling, computer-operated workstations. These issues will be explored through biomechanical motion analysis and physical characteristics assessments. The field eexperiment by using a portable data logger mainly focused on the risk of upper extremity musculoskeletal injury during throwing. I hope that my research findings can contribute to sports performance improvement and injury prevention.

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